059-300 Autismo e Genetica parte 7 (volume terzo)

Uploaded by RotoloGiuseppe on 26.12.2010

We continue with the seventh lecture on autism and genetics. Let's see an article from New York found in Medline
To make it easier to find part provides the link to the article in English and the translation of www.google.it Article in English: www.bit.ly/genetic7 Article in Italian www.bit.ly/genetica7
The paper reports 556% increase in pediatric prevalence between 1991 and 1997
This increase is due, according to the authors, greater diagnostic capacity
The authors point out that autism is not a disease but a syndrome with multiple causes, not genetic
The article goes on to describe some important facts about autism and genetics
Rett syndrome, which is one of pervasive developmental disorders, often have a specific genetic damage, by mutations in the gene methyl-CpG-binding protein 2 (MeCP2)
Also according to the authors other subtypes pervasive developmental disorder not linked to any particular genetic cause
Move towards the idea of interaction of many genes, in complex ways not yet understood finally, the emergence of many cases of autism
We started in the previous lesson that the genome of an organism, also called gene) consists of series of pairs of nitrogenous bases, or nucleotides, distributed on the chromosomes
Then the nitrogen bases form genes all genes form the 23 pairs of chromosomes that every human possesses
Each time a cell replicates all nucleotides of the genome is replicated during DNA synthesis
This is the system that carries the genetic information in plant and animal life
A dysfunction in one or more of these steps leads to a genetically determined or genetically influenced disease
In the videos you see that we have prepared the four nitrogenous bases, adenine, thymine, cytosine and guanine
The sequence of these four bases allows the formation of the double helix of DNA that is visible
Then the sequence of the four nitrogenous bases, adenine, thymine, cytosine and guanine determines the genetic information
On the basis of what information is given by the nitrogen bases of three serious
For example, the sequence cytosine guanine guanine CGG sequence that is information based
The FMR1 gene typically includes a long sequence CGG. In some cases of autism CGG repeat sequence is longer than necessary