Cancer Gene Testing For Breast Cancer Risk In Family

Uploaded by drjayharness on 23.12.2011

>>> DR. DAVID MARGILETH: Prior to our knowing about the BRCA1 and BRCA2 genes, everybody
noticed that there were certain families that had a propensity to develop both breast cancer
and ovarian cancer.

When the BRCA1 gene and subsequently the BRCA2 gene were discovered,
it gave us an opportunity to test patients and separate out those patients and their
families who carry that gene and therefore have an increased risk of breast cancer and
ovarian cancer, for most patients who don’t.

Patients that carry the BRCA1 or BRCA2 gene
had genes that are supposed to stop the development of cancer but are mutated such that cancer
can develop more commonly, and those two cancers are in the breast and the ovary.

When one
looks at a patient or a family that has this gene in the family, the breast cancer rate
can approach 80% and the lifetime ovarian cancer rate can be up to 25% or 40%.

we see patients, we ask the question ‘Is there a family history here that would indicate
that this gene may be present?’, and those questions revolve around the age of the patient,
the age of the other members of the family that had either breast or ovarian cancer,
and the number of those relatives that had those cancers.
Hi, I am Dr. Jay Harness and I want to share with you important information that I believe
that every newly diagnosed patient with breast cancer needs to know.
Susan Denver: I am a breast cancer survivor.
Katherine Stockton: I am a breast cancer survivor.
Coree: I am a breast cancer survivor.
Susan Denver: And I want every woman to know…
Katherine Stockton: …about personalized breast cancer treatment…
Susan Denver: …and the genomic test.
Coree: A test that helps guide a woman and her doctor…
Katherine Stockton: …to the best treatment options for her.
Susan Denver: Pass it on!